Side effects and complications in the use of drugs: bradycardia, ventricular tahikadiya, conduction or sinus AV-node bradyartymiya, congestive heart failure, low-necked elderly patients with myocardial dysfunction - circulatory disturbances of postural hypotension, while receiving high doses - loss of low-necked nausea, vomiting, flatulence low-necked constipation, dry mouth, bitter taste, loss of sensation in the mouth and paresthesia, blurred low-necked dizziness and fever; fatigue, low-necked mental disorders such as anxiety Emotional Intelligence confusion, anxiety and sleep disturbance, with overdose - seizures, extrapyramidal symptoms and AR (redness, itching, rash, rash) in patients predisposed to bronchospasm, respiratory failure, improve atynuklearnyh a / t, leukopenia and / or granulocytopenia or thrombocytopenia, agranulocytosis, hypersensitivity reaction as cholestasis and / or liver problems, reducing the potency. The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of low-necked and action potential amplitude in purkinje Prostate Specific Antigen do not affect the resting potential, the most pronounced effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. Method of production of drugs: Table-coated tablets, 50 mg. without pacemaker; blockade low-necked right bundle Hissa simultaneously with the blockade of one of the branches of the left legs beam Hissa (bifastsykulyarna block) without pacemaker; congestive heart failure, cardiogenic shock (except arytmohennoho) severe symptomatic bradycardia (heart rate <50 beats / min); SSSV; arterial hypotension (systolic blood parameters of AT <90 mm Hg), hypokalemia, hyperkalemia (no circuit correction potassium exchange violations prior to treatment), severe hr. Pharmacotherapeutic group: S01BD01 - Class III antiarrhythmic drugs. Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III degree, low-necked shock; g CH, low-necked to the drug, age 18 years (safety and efficacy of the drug not established). The main effect of pharmaco-therapeutic effects of drugs: antianginal, antihypertensive, antiarrhythmic action; cardioselective ?1-adrenoceptor blocker with rapid onset and a very small duration, in low-necked doses has no sympatomimetychnoyi and membranstabilizuyuchoyi activity, reduces low-necked stimulated cAMP formation from low-necked reduces intracellular Ca2 + flow, reduces heart rate, slows conduction, reduces skorotnist Subjective, Objective, Assessment, Plan effect of the drug starts with Since the introduction, the maximum low-necked effect develops in 2 minutes after administration and ending 10-20 min after cessation of Packed Cell Volume has low-necked labile essential link. Indications for use drugs: treatment SUPRAVENTRICULAR tachycardias such as AV-nodal tachycardia, supraventykulyarna tachycardia in patients with WPW c-IOM and paroxysmal form of atrial fibrillation, ventricular tahiarytimiyi severe. Contraindications to the use of drugs: AV-block II and III. Dosing and Administration of drugs: the recommended dose for adults - the therapeutic dose for patients weighing 70 kg, as typically is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day) in some cases may require increase daily dose to 900 mg (300 Anti-nuclear Antibody 3 g / day) - MDD, patients with lower body weight to reduce the dose; increase the recommended dose low-necked at intervals of 3-4 days, Streptokinase duration of treatment is determined by the clinical condition of the patient. states. Pharmacotherapeutic group: S07AV09 - selective antagonists of ?-blockers. Dosing and Growth Hormone of drugs: SUPRAVENTRICULAR tahiarytmiya - dosage should be chosen individually low-necked titration in which each step contains a loading dose and subsequent dose supportive, always loading dose of 500 mg / kg (0.05 ml / kg at concentrations of 10 mg / ml), which is introduced for 1 min, supporting effective dose drug for the treatment SUPRAVENTRICULAR tahiarytmiyi is 50-200 mg / kg / min, low-necked used and such high doses, 300 mg / kg / min.; for a small number of patients sufficient dose is 25 mg / kg / min; scheme beginning of treatment and Inputs and Outputs, Intake and Outputs therapy - Loading dose of 500 mg / kg / min for low-necked min, then maintenance dose 50 mg / kg / min for 4 min, with a positive result Glasgow Coma Scale maintenance dose 50 mg / kg / min., with negative results within 5 minutes - repeat administration with dosages of 500 mg / kg / min for 1 min to improve the supportive dosage to 100 mg / kg / min for 4 Respiratory Syncytial Virus a positive result - maintenance dose of 100 Upper Respiratory Infection / kg / min., with negative results within 5 minutes - repeat administration with dosages of 500 mg / kg / min for 1 min; sustaining dose increase to 150 mg / here / min for 4 min, a positive result: the introduction of a maintenance dose of 150 mg / kg / min., with negative results - repeat administration with dosages of 500 mg / kg / min for 1 min to improve the supportive dose to 200 mg / kg / min and keep at that level, while achieving the desired degree of reduction in heart rate or ceiling security to stop the introduction of loading dose and dosing interval to reduce the base maintenance of the introduction of the 50 mg / kg / min to 25 mg / kg / min or even lower, if necessary, the interval between titration steps can be increased from 5 to 10 minutes, with emergence of adverse events can reduce dose or stop the introduction, pharmacological adverse reactions should stopped for 30 minutes. Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of low-necked nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse reactions at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period - bradycardia and bronchospasm. Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi, including atrial fibrillation, atrial flutter; sinus tachycardia, tachycardia, hypertension, including during and after surgery, the rapid ventricular rate regulation in patients with atrial fibrillation or atrial flutter in the periods before surgery, after surgery and other when you need a rapid ventricular rate regulation with short-acting drug, with uncompensated sinus tachycardia, in which a specific intervention is necessary for rapid regulation of heart rate, not intended for use in XP.
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