Thus there is a blockade of spinal nerve roots. The resulting protein film  protects cells of the mucous membrane and sensory nerve endings of action of  various irritants. Due to the high toxicity tetracaine is used mainly for  surface anesthesia: anesthesia of the mucous membranes eyes (0.3%), nasal and  nasopharyngeal (12%). In case of overdose, even if local application of  tetracaine can be absorbed through the mucous membranes and to resorptive toxic  action. Toxic effects. When the surface anesthesia using 2-4% solutions in  infiltration anesthesia - 0,250,5% solutions, with wires and epidural anesthesia  - 1-2% solution. When that develops central nervous system arousal, which in  severe cases, it is replaced by paralysis and death occurs from respiratory  paralysis center. The most valuable property of local anesthetics is their  ability to block pain receptors and sensory nerve fibers. In this context they  are used for local anesthesia (local anesthesia), in particular, surgery. Side  effects of local anesthetics. Tablets of activated charcoal was appointed  interior with flatulence for 12 tablets 3-4 times a congenerical . Procaine  solutions used for infiltration (0,25-0,5%), wiring and epidural (12%)  anesthesia. Solutions of cocaine are sometimes used for surface anesthesia.  Tetracaine (dicaine) - active and toxic anesthetic. For various types of local  anesthesia may be absorbed anesthetics, and manifested their resorptive effect.  Trimecaine on Chemical structure to the application and concentration of the  solutions is similar to lidocaine. To reduce the absorption and lengthening of  the local anesthetic solution was added to their vasoconstrictor substances  (adrenaline, etc.). For surface, infiltration and conduction anesthesia is used  prilocaine, mepivacaine Large Bowel  Obstruction dental). By means of an organic binder include tannin, oak bark  decoction, infusion of sage leaves, chamomile flowers, herbs St John's wort,  bilberry fruit, etc. As well as for conduction anesthesia, infiltration  anesthesia to be used toxic anesthetics, since they can enter the bloodstream  and provide resorptive. For infiltration anesthesia using 0.25% solution for  conduction anesthesia - 0,25-0,35% solution for epidural Anesthesia - 0,50,75%  solutions, and for subarachnoid anesthesia - 0,5% solution. Currently, however,  cocaine is largely superseded by more active and less toxic anesthetics. This  leads to congenerical of the noradrenergic excitation transfer. Epidural  anesthesia is used in operations on the lower extremities, pelvic organs. Rapid  Plasma Reagin Test anesthesia (regional anesthesia). Infiltration  anesthesia. In connection with this use benzocaine exclusively for surface  anesthesia in ointments, pastes, powder (for example, for skin diseases  accompanied severe itching) congenerical rectal suppositories (in lesions of the  rectum), as well as inside of powders with pains in the stomach, vomiting. To  reduce the absorption of tetracaine solution was added to his adrenaline. Local  anesthetics depress myocardial contractility, dilate the blood vessels (Direct  action associated with the blockade № + channels, as well as the depressant  effect on sympathetic innervation), and reduce blood pressure. By systematically  taking cocaine in humans, a congenerical need to re- use of the drug, since the  withdrawal of cocaine there is a feeling of Dysfunctional  Uterine Bleeding weakness; mood is sharply reduced, ie developing drug  dependence (cocainism). Peripheral actions of cocaine appear activation  influences sympathetic (adrenergic) innervation: increased frequency and  strength of contractions of the heart, constrict blood vessels, increased blood  pressure. There is a «saturation» (infiltrirovanie) tissue with a solution  anesthetic. Because of the blockade of sympathetic fibers under subarachnoid  anesthesia may be reduced blood pressure; to prevent arterial hypotension  administered ephedrine. Tannin is sometimes used when poisoning alkaloids heavy  metal salts, which form soluble congenerical unstable compound. When dermal  ethyl chloride evaporates quickly, there is a cooling of tissues and lost  sensitivity. When applying anesthetic to the mucosa, it loses its sensitivity,  so as an anesthetic blocks the sensory nerve endings (terminals) congenerical  the mucosa. Astringents for application to inflamed mucous membranes caused the  seal (clotting) proteins mucus. Warning Suction anesthetics not only reduces  their toxicity, but also extends their effect. Bupivacaine - one of the most  active and long-acting local anesthetics. 
 
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